Study Shows AB-Biotics’ Probiotic Strain Improves Mental Health

26-Oct-2022

The formulation of the probiotic strain also relieves stomach upset and increases productivity

Study Shows AB-Biotics' Probiotic Strain Improves Mental Health

A new study published in the peer-reviewed journal Heliyon finds that a blend of three probiotic strains from AB-Biotics, a Kaneka Group company, reduces diarrhea-related symptoms and may improve mental well-being in children. adults regularly subjected to the stresses of modern life.

Researchers Takumi Sato et al. designed the comparative double-blind, placebo-controlled, parallel-group study to investigate the effectiveness of a probiotic blend comprised of strains P. acidilactici KABP 021 (CECT 7483), L plants. KABP 022 (CECT 7484), L plants. KABP 023 (CECT 7485), as a potential treatment for people with “IBS-like” gastrointestinal (GI) symptoms, triggered by repeated exposure to stress. The results of the study suggest that the probiotic blend was successful in meeting the needs of otherwise healthy subjects suffering from stress-induced abdominal symptoms. Additionally, the probiotic has shown a positive effect on individuals’ productivity, mood, and quality of life.

Symptom relief for healthy stress sufferers

It is estimated that 4% of the world’s population suffers from irritable bowel syndrome (IBS). An already significant statistic, this number does not take into account the millions of people around the world who suffer from milder or undiagnosed “IBS-like” conditions, which are often linked to stress, depression and anxiety.

In their study, Sato et al. set out to explore the potential of a probiotic formulation for subjects in this category, who present with symptoms such as diarrhea, but remain outside the medical diagnosis of IBS. Japan was chosen as the study location due to the prevalence of highly competitive work environments, fast-paced modern lifestyles, and IBS-like medical conditions. Twenty-six female and thirty-four male volunteers between the ages of 20 and 65 were selected for the study, who were randomly assigned to the probiotic or placebo group who were both instructed to take one capsule daily for a period of four weeks.

Through our commitment to scientific excellence, safety and efficacy, we will continue to support research that strengthens our understanding of the role probiotics play in gut, immune and mental health.

Results collected from this month-long survey demonstrated that the AB-Biotics probiotic blend helped to reduce stress-related diarrhea and total diarrhea scores in the probiotic group compared to placebo, as assessed by Izumo scale scores. These subjects also reported improved health-related quality of life scores measured using the SF-8 questionnaires, suggesting improved mental health and well-being during the study. Sato et al. hypothesized that these particular bacterial strains counteract the harmful effects of stress on the intestinal mucosa by producing metabolites, such as polyphosphates, acetylcholine or acetate, which are known to reduce intestinal permeability and inflammation intestinal, with positive gastrointestinal benefits.

The researchers also found a significant correlation between the increase in the number of butyric acid producers Faecalibacterium prausnitzii and improvement in diarrhea scores in subjects receiving probiotics but not in the placebo group. In accordance with this, Faecalibacterium is known to be boosted by acetate, one of the substances produced by the probiotic blend. Based on these results, Sato et al. propose that probiotic intervention directly reduces gut permeability and modulates gut microbiota, supporting beneficial bacteria, such as Faecalibacterium.

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The findings of this new study are supported by existing research with the same probiotic formulation, which showed improvements in visceral hypersensitivity, a component of IBS linked to impaired perception of gastrointestinal symptoms. This new study confirms that the probiotic modulates the gut-brain axis, with benefits observed in the gut and also emotional well-being. Overall, these probiotic strains have shown strong scientific results for complex gastrointestinal disorders like stress-related diarrhea, IBS, and food intolerances, including lactose and fructose intolerance. Importantly, these results were observed across different ethnicities and diets, reinforcing the usefulness of these strains.

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“Gold standard, randomized, double-blind, placebo-controlled clinical trials are our daily bread,” said Miquel Bonachera, co-founder and director of AB-Biotics. “We are extremely pleased to announce the results of this latest study, but this is just the beginning. Through our commitment to scientific excellence, safety and efficacy, we will continue to support research that strengthens our understanding of the role probiotics play in gut, immune and mental health – and their life-transforming potential. people. Watch this place!”

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