chronic disease Archives

Adadagrasib provides antitumor activity against KRAS G12C mutant metastatic colorectal cancer, both as monotherapy and in combination with cetuximab | Medicine in 2 Minutes

1. Overall tumor response to adagrasib monotherapy treatment was 23% 46% in combination with cetuximab. 2. Median progression-free survival was 5.6 months on adagrasib monotherapy and 6.9 months on combination therapy with cetuximab. Level of evidence assessment: 2 (Good) Summary of the study: Rat sarcoma virus oncogene homolog Kirsten (KRAS) is responsible for oncogenesis in …

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Metformin monotherapy not always the best start in type 2 diabetes

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Metformin failure in people with type 2 diabetes is very common, especially in those with elevated A1c levels at diagnosis, new findings suggest. An analysis of electronic health record data from more than 22,000 patients starting metformin at three US clinical sites found that more than 40% experienced metformin failure. This was defined as the …

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Gardening may help reduce cancer risk and improve mental health

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Share on PinterestNew research suggests that gardening provides various health benefits, including a reduced risk of chronic diseases like cancer. Manu Prats/Stocksy A new study shows that people who work in community gardens experience various health benefits that can help reduce the risk of chronic diseases like cancer and can improve mental health. The randomized …

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Emraclidine Is Safe and Well Tolerated for the Treatment of Schizophrenia | Medicine in 2 Minutes

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1. The incidence of total adverse events and specific adverse events was similar between the emraclidine and placebo groups. 2. There was an initial modest increase in heart rate and blood pressure with emraclidine that was not judged to be clinically significant at week 6. Level of evidence assessment: 1 (Excellent) Summary of the study: …

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Healthcare Leadership: Making Medicine a Team Sport

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Tony Thomas, a graduate nurse from New York, reunites with the medical team at St. Francis Hospital … [+] which helped him out of a 39-day battle with COVID-19 in June 2020. Newsday via Getty Images Americans pay lip service to the importance of teamwork. But more often than not, we attribute success to individuals. …

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No difference in clinical outcomes between joint replacement and fusion surgeries for ankle osteoarthritis | Medicine in 2 Minutes

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1. In patients with end-stage ankle osteoarthritis, no difference was observed in outcomes between total ankle replacement (TAR) and ankle fusion (AF) surgeries. 2. There were no significant differences in the rate of adverse events in patients who received ART compared to AF surgeries. Level of evidence assessment: 1 (Excellent) Summary of the study: Surgical …

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#VisualAbstract: Early mobilization after mechanical ventilation in intensive care does not improve survival | Medicine in 2 Minutes

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1. Early mobilization of patients after mechanical ventilation in the intensive care unit (ICU) did not lead to an improvement in the number of days alive and out of hospital. 2. Early mobilization was associated with more adverse events than routine care. Level of evidence assessment: 1 (Excellent) Overview of the study: Patients with severe …

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Vitamin D Supplementation Is Not Preventative for Statin-Associated Muscle Symptoms or Statin Discontinuation | Medicine in 2 Minutes

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1. A randomized controlled trial found that pretreatment with vitamin D supplementation did not reduce the risk of statin-associated muscle symptoms in adult patients. 2. Vitamin D supplementation also did not reduce the risk of statin discontinuation. Assessment of the level of proof: 1 (Excellent) Summary of the study: Statins are among the most commonly …

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ENT-01 reduces constipation rates in patients with Parkinson’s disease | Medicine in 2 Minutes

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1. Compared to placebo, ENT-01 increased weekly complete spontaneous stool rates in patients with Parkinson’s disease (PD). 2. No serious adverse events occurred with the use of ENT-01 and the most frequently reported adverse effect was nausea. Level of evidence assessment: 1 (Excellent) Summary of the study: Non-motor symptoms of PD can significantly impair a …

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The Importance of Diabetes Coverage in a Health Insurance Plan – ET HealthWorld

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By Priya Deshmukh Gilbile Diabetes is known to be one of the most common chronic diseases which, if left untreated, can lead to serious health issues, such as heart disease, vision loss, and kidney disease. Alarmingly, India has the second largest adult diabetes population in the world. According to the Indian Council of Media Research …

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