Enzyme causes cognitive decline in mice and provides new target for Alzheimer’s disease
Newswise — In a recent search for genetic variants associated with Alzheimer’s disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members carrying this mutation had Alzheimer’s disease; those without the mutation did not. The M489V mutation has since been shown to increase PKCα activity by a …
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